The future of method development for liquid chromatography

Welcome to Analytically Speaking, the new podcast from LCGC and Spectroscopy.

In this episode, podcast host Dr. Dwight Stoll talks to Dr. Deidre Cabooter, Professor in the Department of Pharmaceutical and Pharmacological Sciences at KU Leuven in Leuven, Belgium, about his journey to the science of separation, her research on fundamental aspects of band broadening of liquid chromatography and emerging work on the use of machine learning in method development, and her work as an organizer of the HTC conference and editor-in-chief of Chromatography Journal A. Drs. Stoll and Cabooter talk about the importance of continuing to dig deeper and better understand dispersion processes nearly 70 years after the publication of van Deemter’s famous equation, as well as the growing importance of multidimensional separations in various fields of research.

Useful links:

Recent literature discussed:

  • D. Sadriaj, G. Desmet, D. Cabooter, Taylor-Aris Methodology for the Experimental Determination of Molecular Diffusion Coefficients: A Tutorial Focused on Large Biomolecules. Chromatography Journal, A 1664, in press (2022).
  • G. Loos, K. Shoykhet, M. Dittmann, D. Cabooter, Restriction capillaries as an innovative mixing unit for intermediate mobile phase exchange in multidimensional analysis. Chromatography Journal, A 1497, 70-80 (2017).
  • A. Kensert, G. Collaerts, K. Efthymiadis, G. Desmet, D. Cabooter, Deep Q-learning for the selection of optimal isocratic analyzes in liquid chromatography. Chromatography Journal, A 1638, in press (2021).
  • A. Kensert, R. Bouwmeester, K. Efthymiadis, P. Van Broeck, G. Desmet, D. Cabooter, Graph Convolutional Networks for Better Prediction and Interpretability of Chromatographic Retention Data. Analytical Chemistry 93(47) 15633-15641 (2021).

Learn more about our hosts:

Dwight Stoll, PhD:

Dwight R. Stoll is a professor of chemistry at Gustavus Adolphus College in St. Peter, Minnesota. He obtained his PhD from the University of Minnesota, under the supervision of Professor Peter Carr, working on the development of rapid and comprehensive two-dimensional liquid chromatography (2D-LC). Stoll’s current main research focus is the development of 2D-LC for targeted and non-targeted analyses. Active research projects in his lab touch on most aspects of multidimensional separation methodologies, including optimization strategies, characterization of reverse-phase LC selectivity, instrument development, and applications in biopharmaceutical analysis. Stoll has authored or co-authored over 80 peer-reviewed publications and six book chapters and has taught numerous 2D-LC short courses. In 2011, he was the recipient of LCGC Emerging Leader in Chromatography Award. In 2017, he received the Georges Guiochon Research Grant and was awarded the Agilent Technologies Thought Leader Award. He is also a member of LCGC editorial advisory board and is the editor of the “LC Troubleshooting” column in LCGC.

Jerome Workman, Jr., PhD:

Jerome (Jerry) J. Workman, Jr. is Senior Technical Writer for LCGC and Spectroscopy. He has held CTO, EVP, Principal Researcher, Director, and Principal Scientist positions at companies of all sizes, from start-ups to world-renowned corporations. He has served as an adjunct faculty member at four universities and has advised several graduate students. He has over 75 U.S. and international patent applications and 30 issued U.S. and international patents and multiple trade secrets, as well as over 500 technical publications and 20 volumes of reference works on a wide range of spectroscopy and processing techniques. of data. He has received several awards from scientific societies and has taught annual courses in spectroscopy, chemometrics and statistics for AOAC, ACS, ISA, FACSS and several universities and companies. He is a member of the American Institute of Chemists (FAIC), the American Society for Testing and Materials (ASTM) and the Royal Society of Chemistry in the UK (FRSC, CChem, CSci). Jerry holds bachelor’s and master’s degrees from Saint Mary’s University of Minnesota and a Ph.D. from Columbia Pacific University in near-infrared spectroscopy. He is an alumnus of Columbia University Business School and MIT Sloan School of Management.

About the Analytically Speaking Podcast:

Analytically Speaking, the podcast of LCGC and Spectroscopy, addresses important issues in separation sciences and analytical spectroscopy. Topics include new analytical techniques, methods and approaches; the latest trends; advances in instrument and software technology; practical solutions for specific applications; recent articles in the scientific literature and their applicability; challenges and solutions for data analysis and interpretation; theory and fundamentals of analytical chemistry (from advanced research to tutorials and troubleshooting); and more. Our regular hosts are Dwight Stoll, PhD, Professor of Chemistry at Gustavus Adolphus College in St. Peter, Minnesota, and Jerry Workman, PhD, Spectroscopist, renowned author and currently Senior Technical Editor of Spectroscopy and LCGC. Dwight covers the science of separation and Jerry covers topics related to spectroscopy.

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